The challenges that must be overcome by a body that has been "doused" with nutritional supplements demonstrates the truth of the old saying, "You can have too much of a good thing." The ingestion of too many nutritional supplements can interfere with the intricacies of the body’s biochemistry. It can produce a harmful imbalance in the body’s existing nutrients.

Nutritional supplements that contain any of the fat-soluble vitamins can cause a build-up of that vitamin within the body. A build-up of Vitamin A or D can damage the liver, kidney or bones. Still, a nutritional supplement does not have to contain a fat soluble vitamin in order have the potential to inflict harm on the person using it.

Some nutritional supplements contain the water soluble substance called pyridoxine. Pyridoxine has the ability to diminish pre-menstrual bloating, and used in moderation it typically offers important benefits. If used in excess, however, pyridoxine can cause numbness of the mouth and tingling of the hands, signs of neurological damage.

When purchasing any of the nutritional supplements, the wise consumer should seek to discover the exact contents of that supplement. Certain chemicals can trigger migraine headaches, and those chemicals would not serve as a helpful addition to any of the nutritional supplements.

Phenyl ethylamine and histamine are both vasoactive chemicals. They act on blood vessels, and in doing so, they cause migraine headaches. Tyramine and other amines are also capable of causing migraines. None of the above chemicals makes a desirable addition to any of the nutritional supplements.

Ingestion of the wrong nutritional supplement cannot only trigger an unhealthful change, it can also block the beneficial actions of certain medications. For example, nutritional supplements that contain folate can block the action of an anti-seizure medication.